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BAMBI Antibody (PA5-100127) in ICC/IF
Immunofluorescent analysis of BAMBI in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and BAMBI polyclonal antibody (Product # PA5-100127) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-100127
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human BAMBI(Accession Q13145), corresponding to amino acid residues S178-T228.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2815657
产品详细信息
Antibody detects endogenous levels of total BAMBI.
靶标信息
BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA) is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development. BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4. BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues. BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BMP and activin membrane-bound inhibitor homolog; BMP and activin membrane-bound inhibitor, homolog; Kinase-deficient TGFbeta superfamily receptor subunit; Non-metastatic gene A protein; Putative transmembrane protein NMA
基因别名: 2610003H06Rik; BAMBI; NMA
UniProt ID: (Human) Q13145, (Rat) Q91XN4, (Mouse) Q9D0L6
Entrez Gene ID: (Human) 25805, (Rat) 83837, (Mouse) 68010
transforming growth factor beta receptor signaling pathway
positive regulation of cell proliferation
regulation of cell shape
positive regulation of epithelial to mesenchymal transition
cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of protein binding
positive regulation of catenin import into nucleus
positive regulation of transcription, DNA-templated
positive regulation of canonical Wnt signaling pathway
