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BAMBI Antibody (PA5-93037) in WB
Western blot was performed using Anti-BAMBI Polyclonal Antibody (Product # PA5-93037) and a ~40 kDa band corresponding to BMP and activin membrane-bound inhibitor homolog was detected in Mouse Mammary Gland tissue and not in Mouse Brain or Skeletal Muscle which are reported low expressing for BAMBI. Uncharacterized bands (*) at ~45 kDa, ~80 kDa and ~110 kDa are also detected in the low expressing models. Tissue extracts (30 µg lysate) of Mouse Mammary Gland (Lane 1), Mouse Brain (Lane 2), Mouse Skeletal Muscle (Lane 3) were electrophoresed... View More
产品信息
PA5-93037
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 21-152 of human BAMBI (NP_0364741)
偶联物
形式
Liquid
浓度
0.19 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806598
产品详细信息
Immunogen sequence: VLLTKGEIRC YCDAAHCVAT GYMCKSELSA CFSRLLDPQN SNSPLTHGCL DSLASTTDIC QAKQARNHSG TTIPTLECCH EDMCNYRGLH DVLSPPRGEA SGQGNRYQHD GSRNLITKVQ ELTSSKELWF RA; Positive Samples: A-549, Rat heart; Cellular Location: Membrane, Single-pass type I membrane protein
靶标信息
BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA) is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development. BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4. BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues. BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BMP and activin membrane-bound inhibitor homolog; BMP and activin membrane-bound inhibitor, homolog; Kinase-deficient TGFbeta superfamily receptor subunit; Non-metastatic gene A protein; Putative transmembrane protein NMA
基因别名: BAMBI; NMA
UniProt ID: (Human) Q13145, (Rat) Q91XN4
Entrez Gene ID: (Human) 25805, (Rat) 83837
transforming growth factor beta receptor signaling pathway
positive regulation of cell proliferation
regulation of cell shape
positive regulation of epithelial to mesenchymal transition
cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of protein binding
positive regulation of catenin import into nucleus
positive regulation of transcription, DNA-templated
positive regulation of canonical Wnt signaling pathway
