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Immunogen sequence: PVANAFQLER PHFTLPGTMV EGQMERSQNW GHPGVRQETG DEPKGEKEKK EEEKEQEEEE DPYTFAEIDD SEYDMILANL SIKKKTGSRS FIINRPPAPT PRPTSIPPKE ETTPYIAQVF QQKTARRQSD DDKFRGLPKK QDRARIESPA FSTLRGCLTD GQEELILLQE KVKNGKMSMD EALEKFKHWQ MGKSGLEMIQ QEKLRQLRDC IIGKRPEEEN VYNKLTIVHH PGGKETAHNE NKFYNVHFSN KLPARPQVEK EFGFCCKKDH; Positive Samples: B cells, Raji, U-87MG, A-549, 22Rv1, HepG2, Mouse liver, Rat liver
The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: B-cell scaffold protein with ankyrin repeats; B-cell scaffold protein with ankyrin repeats 1 delta 2 transcript; Protein AVIEF
基因别名: A530094C12Rik; AI451642; AVIEF; BANK; BANK1; LRRGT00104
UniProt ID: (Human) Q8NDB2, (Mouse) Q80VH0
Entrez Gene ID: (Human) 55024, (Rat) 365948, (Mouse) 242248