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BCL11A Antibody (PA5-114898) in IHC (P)
Immunohistochemistry analysis of BCL11A in rat brain tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-114898) at a dilution of 1:100. Secondary staining was applied with HRP conjugated goat anti-rabbit.
产品信息
PA5-114898
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human BCL11A(Accession Q9H165), corresponding to amino acid residues T180-I230.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899534
产品详细信息
Antibody detects endogenous levels of total BCL11A.
靶标信息
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B-cell CLL/lymphoma 11A; B-cell CLL/lymphoma 11A (zinc finger protein); B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2; B-cell lymphoma/leukemia 11A; BCL-11A; BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1; C2H2-type zinc finger protein; COUP-TF interacting protein 1; COUP-TF-interacting protein 1; ecotropic viral integration site 9 homolog; Ecotropic viral integration site 9 protein; Ecotropic viral integration site 9 protein homolog; EVI-9; FLJ10173; FLJ34997; myeloid leukemia; Zinc finger protein 856
基因别名: 2810047E18Rik; BCL-11A; BCL11A; BCL11A-L; BCL11a-M; BCL11A-S; BCL11A-XL; CTIP1; D930021L15Rik; EVI9; Evi9a; Evi9b; Evi9c; HBFQTL5; KIAA1809; mKIAA1809; ZNF856
UniProt ID: (Human) Q9H165, (Mouse) Q9QYE3
Entrez Gene ID: (Human) 53335, (Rat) 305589, (Mouse) 14025
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
metal ion binding
transcription corepressor activity
protein heterodimerization activity
nucleic acid binding
protein binding
DNA-binding transcription factor
zinc finger transcription factor
C2H2 zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
signal transduction
protein sumoylation
negative regulation of gene expression
positive regulation of neuron projection development
negative regulation of neuron projection development
B cell differentiation
T cell differentiation
negative regulation of collateral sprouting
positive regulation of collateral sprouting
regulation of dendrite development
negative regulation of nucleic acid-templated transcription
negative regulation of dendrite development
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
