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产品信息
PA5-68505
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the C-terminal region of mouse BCL11A
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2690140
产品详细信息
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Rat: 92%
靶标信息
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.
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生物信息学
蛋白别名: B-cell CLL/lymphoma 11A; B-cell CLL/lymphoma 11A (zinc finger protein); B-cell lymphoma/leukemia 11A; BCL-11A; COUP-TF interacting protein 1; COUP-TF-interacting protein 1; Ecotropic viral integration site 9 protein; EVI-9; FLJ10173; FLJ34997; myeloid leukemia
基因别名: 2810047E18Rik; BCL-11A; Bcl11a; Ctip1; D930021L15Rik; Evi9; Evi9a; Evi9b; Evi9c; Kiaa1809; mKIAA1809
UniProt ID: (Mouse) Q9QYE3
Entrez Gene ID: (Mouse) 14025
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
nucleic acid binding
transcription corepressor activity
protein binding
metal ion binding
protein heterodimerization activity
DNA-binding transcription factor
zinc finger transcription factor
C2H2 zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of gene expression
positive regulation of neuron projection development
negative regulation of neuron projection development
protein sumoylation
B cell differentiation
T cell differentiation
negative regulation of collateral sprouting
positive regulation of collateral sprouting
regulation of dendrite development
negative regulation of nucleic acid-templated transcription
negative regulation of dendrite development
