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产品信息
H00000602-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
BCL3 (NP_005169.1, 1 a.a. approximately 446 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MDEGPVDLRT RPKAAGLPGA ALPLRKRPLR APSPEPAAPR GAAGLVVPLD PLRGGCDLPA VPGPPHGLAR PEALYYPGAL LPLYPTRAMG SPFPLVNLPT PLYPMMCPME HPLSADIAMA TRADEDGDTP LHIAVVQGNL PAVHRLVNLF QQGGRELDIY NNLRQTPLHL AVITTLPSVV RLLVTAGASP MALDRHGQTA AHLACEHRSP TCLRALLDSA APGTLDLEAR NYDGLTALHV AVNTECQETV QLLLERGADI DAVDIKSGRS PLIHAVENNS LSMVQLLLQH GANVNAQMYS GSSALHSASG RGLLPLVRTL VRSGADSSLK NCHNDTPLMV ARSRRVIDIL RGKATRPAST SQPDPSPDRS ANTSPESSSR LSSNGLLSAS PSSSPSQSPP RDPPGFPMAP PNFFLPSPSP PAFLPFAGVL RGPGRPVPPS PAPGGS
靶标信息
B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells. Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B-cell leukemia/lymphoma 3; B-cell lymphoma 3 protein; B-cell lymphoma 3-encoded protein; BCL-3; Bcl-3 protein; chronic lymphatic leukemia protein; Proto-oncogene BCL3
基因别名: BCL3; BCL4; D19S37
UniProt ID: (Human) P20749
Entrez Gene ID: (Human) 602
protein import into nucleus, translocation
follicular dendritic cell differentiation
marginal zone B cell differentiation
humoral immune response mediated by circulating immunoglobulin
germinal center formation
transcription, DNA-templated
cellular response to DNA damage stimulus
I-kappaB kinase/NF-kappaB signaling
response to virus
response to UV-C
antimicrobial humoral response
extracellular matrix organization
DNA damage response, signal transduction by p53 class mediator
positive regulation of interferon-gamma production
T-helper 1 type immune response
regulation of NF-kappaB import into nucleus
negative regulation of tumor necrosis factor biosynthetic process
defense response to bacterium
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
defense response to protozoan
regulation of apoptotic process
negative regulation of apoptotic process
T-helper 2 cell differentiation
positive regulation of interleukin-10 biosynthetic process
negative regulation of interleukin-8 biosynthetic process
positive regulation of translation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
spleen development
regulation of DNA binding
maintenance of protein location in nucleus
