Invitrogen

BIN2 Polyclonal Antibody

BIN2 Antibody in Immunohistochemistry (IHC)

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BIN2 Antibody (PA5-58486) in IHC

Immunohistochemical staining of BIN2 in human bone marrow, liver, lymph node and pancreas using BIN2 Polyclonal Antibody (Product # PA5-58486) (A) shows similar protein distribution across tissues to an independent BIN2 Polyclonal Antibody (B).

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BIN2 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of BIN2 demonstrates antibody specificity. Immunohistochemical analysis of BIN2 using anti-BIN2 Polyclonal Antibody (Product # PA5-58486), shows significant staining of BIN2 in human bone marrow and shows minimal or weak staining in human pancreas tissues. The relative expression levels of BIN2 within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-58486

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化（石蜡） (IHC (P))

1:200-1:500

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human BIN2. Recombinant protein control fragment (Product #RP-97670).

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2638558

产品详细信息

Immunogen sequence: EKPVRTPEAK ENENIHNQNP EELCTSPTLM TSQVASEPGE AKKMEDKEKD NKLISADSSE GQDQLQVSMV PENNNLTAPE PQEEVSTSEN PQL

Highest antigen sequence identity to the following orthologs: Mouse - 29%, Rat - 31%.

靶标信息

BAR proteins, which are characterized by a common N-terminal BAR domain, are a family of adaptor proteins implicated in a diverse set of cellular processes. BIN1 (bridging integrator 1) and BIN2 are BAR proteins. The human BIN2 gene is located at chromosome 4q22.1, and encodes a 565-amino acid protein with a predicted molecular weight of ~62 kDa. It shows preferential expression in hematopoietic tissues, with highest mRNA levels in spleen and peripheral blood leukocytes and also high levels in thymus, colon, and placenta. BIN2 has been shown to migrate with an apparent mobility of ~80 kDa, and interact with BIN1.

仅用于科研。不用于诊断过程。未经明确授权不得转售。