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BLM Antibody (A300-572A) in WB
Detection of human and mouse BLM by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, and mouse NIH 3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-BLM antibody (Product # A300-572A) (lot A300-572A-2) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
产品信息
A300-572A
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 1375 and the C-terminus (residue 1416) of mouse Bloom Syndrome Homolog.
偶联物
形式
Liquid
浓度
0.20 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
靶标信息
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bloom syndrome homolog; Bloom syndrome protein; Bloom syndrome protein homolog; Bloom syndrome, RecQ helicase-like; DNA 3'-5' helicase BLM; DNA helicase, RecQ-like type 2; mBLM; MGC126616; MGC131618; MGC131620; RecQ helicase homolog; RecQ protein-like 3; RecQ-like DNA helicase BLM; RecQ2
基因别名: BLM; BS; RECQ2; RECQL2; RECQL3
UniProt ID: (Human) P54132, (Mouse) O88700
Entrez Gene ID: (Human) 641, (Mouse) 12144
bubble DNA binding
p53 binding
single-stranded DNA binding
ATP-dependent DNA helicase activity
helicase activity
protein binding
ATP binding
ATP-dependent helicase activity
four-way junction helicase activity
ATPase activity
annealing helicase activity
ATP-dependent 3'-5' DNA helicase activity
G-quadruplex DNA binding
nucleotide binding
nucleic acid binding
DNA binding
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
DNA helicase
regulation of cyclin-dependent protein serine/threonine kinase activity
double-strand break repair via homologous recombination
DNA double-strand break processing
DNA synthesis involved in DNA repair
strand displacement
DNA strand renaturation
DNA replication
DNA repair
DNA recombination
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
response to X-ray
protein sumoylation
replication fork processing
DNA duplex unwinding
positive regulation of transcription, DNA-templated
negative regulation of DNA recombination
replication fork protection
protein oligomerization
negative regulation of cell division
cellular response to ionizing radiation
cellular response to hydroxyurea
cellular response to camptothecin
regulation of signal transduction by p53 class mediator
telomere maintenance
cellular metabolic process
negative regulation of mitotic recombination
alpha-beta T cell differentiation
positive regulation of alpha-beta T cell proliferation
regulation of binding
chromosome organization
negative regulation of thymocyte apoptotic process
