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产品信息
PA5-69440
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide corresponding to a region of rat BMP-10 (aa 91-140).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2689403
产品详细信息
This target displays homology in the following species: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
靶标信息
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-beta superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation. It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes. BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BMP; BMP-10; bmp10 {ECO:0000312|EMBL:BAE16990.1, ECO:0000312|RGD:1562986}; Bone morphogenetic protein; Bone morphogenetic protein 10
基因别名: Bmp10
UniProt ID: (Rat) Q4AEG6
Entrez Gene ID: (Rat) 500245
cell adhesion
heart development
adult heart development
negative regulation of endothelial cell migration
positive regulation of cardiac muscle hypertrophy
negative regulation of cardiac muscle hypertrophy
positive regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of cell growth
negative regulation of cell migration
BMP signaling pathway
activin receptor signaling pathway
regulation of apoptotic process
regulation of MAPK cascade
sarcomere organization
positive regulation of transcription, DNA-templated
atrial cardiac muscle tissue morphogenesis
ventricular cardiac muscle tissue morphogenesis
ventricular cardiac muscle cell development
regulation of cardiac muscle contraction
cardiac muscle cell proliferation
positive regulation of cardiac muscle cell proliferation
positive regulation of sarcomere organization
heart trabecula formation
pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
regulation of cardiac muscle hypertrophy in response to stress
positive regulation of cell proliferation involved in heart morphogenesis
