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BMP-15 Antibody (PA5-95615) in IHC (P)
Immunohistochemistry analysis of BMP-15 in paraffin-embedded human intestinal cancer tissue. Antigen retrieval was performed on the tissue using citrate buffer (pH 6, 20 min) and blocked with 10% goat serum. Samples were incubated with BMP-15 polyclonal antibody (Product # PA5-95615) at a 1 µg/mL dilution, followed by biotinylated goat anti-rabbit IgG (30 min, 37°C), and developed with Strepavidin-Biotin-Co... View More
Product Details
PA5-95615
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence of human BMP15 (KGTCLRVLRDGLNSPNHAIIQNLINQLVDQ).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2807417
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human placenta tissue, human Caco-2 whole cell, rat lung tissue, mouse lung tissue. IHC: mouse lung tissue, human gastric cancer tissue, human intestinal cancer tissue, human lung cancer tissue, human ovary cancer tissue, human placenta tissue, human prostatic cancer tissue, human thyroid cancer tissue, human tonsil tissue, rat lung tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
BMP15, or GDF9B is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily that are involved in embryonic development and adult tissue homeostasis. BMP15 is expressed exclusively in the oocyte. It is an oocyte-specific growth/differentiation factor that may be involved in oocyte maturation and follicular development. Defects in BMP15 are the cause of ovarian dysgenesis type 2. BMP15 could be used as an oogenesis marker to track human amniotic fluid stem cells differentiation into the oocyte-like cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP; BMP-15; Bone morphogenetic protein; Bone morphogenetic protein 15; GDF-9B; growth differentiation factor-9B; Growth/differentiation factor 9B
Gene Aliases: AU015375; AU018861; AU021453; Bmp-15; BMP15; C86824; C87336; GDF-9B; GDF9B; ODG2; POF4
UniProt ID: (Human) O95972, (Mouse) Q9Z0L4
Entrez Gene ID: (Human) 9210, (Rat) 59302, (Mouse) 12155
ovarian follicle development
positive regulation of pathway-restricted SMAD protein phosphorylation
BMP signaling pathway
regulation of apoptotic process
regulation of MAPK cascade
positive regulation of transcription, DNA-templated
cell development
granulosa cell development
SMAD protein signal transduction
female gamete generation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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