Invitrogen

BMP-5 Polyclonal Antibody

BMP-5 Antibody in Immunohistochemistry (Frozen) (IHC (F))

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BMP-5 Antibody (PA5-47821) in IHC (F)

Immunohistochemical analysis of BMP-5 in immersion fixed frozen sections of mouse embryo (13 d.p.c.). Samples were incubated in BMP-5 polyclonal antibody (Product # PA5-47821) using a dilution of 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to developing brain and musc... View More

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产品信息

PA5-47821

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

免疫组化（冰冻） (IHC (F))

5-15 µg/mL

产品规格

种属反应

Mouse

宿主/亚型

Sheep / IgG

分类

Polyclonal

类型

Antibody

抗原

CHO-derived recombinant mouse BMP-5 Ala315-His452

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5% trehalose

内含物

No Preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2608675

产品详细信息

In Western blots, approximately 20% cross-reactivity with recombinant human BMP-5 is observed. In direct ELISAs, approximately 100% cross-reactivity with recombinant human BMP-5 is observed, and approximately 4% cross-reactivity with recombinant mouse (rm) BMP-6 and rmBMP-7 is observed, and less than 1% cross-reactivity with rmBMP-8b is observed.

Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

靶标信息

TGF-ß family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth, and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling, and maintenance of a variety of other tissues and organs. BMP-5 is expressed in the nervous system, lungs and liver. It is a known regulator for dendritic growth in sympathetic neurons. BMP-5 is a 454 amino acid precursor protein that is cleaved to release the biologically active C-terminal mature protein.

仅用于科研。不用于诊断过程。未经明确授权不得转售。