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产品信息
H00000653-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
BMP5 (NP_066551, 1 a.a. approximately 454 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MHLTVFLLKG IVGFLWSCWV LVGYAKGGLG DNHVHSSFIY RRLRNHERRE IQREILSILG LPHRPRPFSP GKQASSAPLF MLDLYNAMTN EENPEESEYS VRASLAEETR GARKGYPASP NGYPRRIQLS RTTPLTTQSP PLASLHDTNF LNDADMVMSF VNLVERDKDF SHQRRHYKEF RFDLTQIPHG EAVTAAEFRI YKDRSNNRFE NETIKISIYQ IIKEYTNRDA DLFLLDTRKA QALDVGWLVF DITVTSNHWV INPQNNLGLQ LCAETGDGRS INVKSAGLVG RQGPQSKQPF MVAFFKASEV LLRSVRAANK RKNQNRNKSS SHQDSSRMSS VGDYNTSEQK QACKKHELYV SFRDLGWQDW IIAPEGYAAF YCDGECSFPL NAHMNATNHA IVQTLVHLMF PDHVPKPCCA PTKLNAISVL YFDDSSNVIL KKYRNMVVRS CGCH
靶标信息
TGF-ß family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth, and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling, and maintenance of a variety of other tissues and organs. BMP-5 is expressed in the nervous system, lungs and liver. It is a known regulator for dendritic growth in sympathetic neurons. BMP-5 is a 454 amino acid precursor protein that is cleaved to release the biologically active C-terminal mature protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BMP; BMP 5; BMP-5; bone morphogenenic protein-5; Bone morphogenetic protein; Bone morphogenetic protein 5; MGC34244
基因别名: BMP5
UniProt ID: (Human) Q9H547
Entrez Gene ID: (Human) 653
skeletal system development
ossification
type B pancreatic cell development
pattern specification process
negative regulation of cell proliferation
negative regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of steroid biosynthetic process
BMP signaling pathway
male genitalia development
negative regulation of aldosterone biosynthetic process
growth
regulation of apoptotic process
regulation of MAPK cascade
negative regulation of insulin-like growth factor receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of epithelial cell proliferation
cartilage development
SMAD protein signal transduction
negative regulation of mononuclear cell migration
positive regulation of dendrite development
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of cortisol biosynthetic process
positive regulation of DNA-dependent DNA replication
