Invitrogen

CD102 (ICAM-2) Monoclonal Antibody (CBR-IC2/2), Biotin, eBioscience™

产品信息

BMS109BT

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

Assay-Dependent

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

CBR-IC2/2

偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

10 µL/Test

纯化类型

Affinity chromatography

保存液

TBS, pH 7.2-7.4, with 1% BSA

内含物

0.02% sodium azide

保存条件

2-8°C

运输条件

Ambient (domestic); Wet ice (international)

AB_10596975

产品详细信息

Description: BMS109 does not cross react with mouse.

Intercellular Adhesion Molecule-2 (ICAM-2) is a 60 kDa surface glycoprotein that promotes adhesion between immune cells and the vascular endothelium. ICAM-2 is a member of the Ig-superfamily with two immunoglobulin-like extracellular domains. ICAM-2 is much more closely related to the two N-terminal domains of ICAM-1 (34% identity) than either ICAM-1 or ICAM-2 is to other members of the Ig-superfamily, demonstrating the existence of a subfamily of Ig-like ligands that bind the same integrin receptor. ICAM-2 is broadly distributed on hematopoietic cells. On resting lymphocytes, the ICAM-2 expression is several-fold higher than that seen with ICAM-1, while monocytes express equivalent levels of ICAM-1 and ICAM-2. In contrast to ICAM-1, neutrophils stain negative for ICAM-2. Just little or no ICAM-2 staining can be demonstrated on other cell lines, the sole exception being resting vascular endothelial cells, which possess high levels of ICAM-2, and small clusters of cells in lymphoid tissue germinal centres.

ICAM-2 expression is unaffected by a variety of inflammatory cytokines.

Applications Tested: Flow Cytometry.

Purity: >95%.

靶标信息

ICAM-2 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. ICAM-2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. Diseases associated with ICAM2 include Colon Carcinoma In Situ.

仅用于科研。不用于诊断过程。未经明确授权不得转售。