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产品信息
PA5-55438
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2638571
产品详细信息
Immunogen sequence: VELKEEWQDE DFPIPLPEDD SIEADILAIT GPEDQPGSLE VNGNKVRKKL MAPDISLTLD PSDGSVLSDD LDESGEIDLD GLDTPSENSN EFEWEDDLPK PKTTEVIRKG SITEYTAAEE KEDGRRWRMF RIGEQDHRV
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
靶标信息
BNIP-2, (previously designated Nip2 and Nip21 in human and mouse respectively), shares homology with the non-catalytic domain of Cdc42 GTPase-activating protein (Cdc42GAP). Through binding to Cdc42GAP, BNIP-2 enhances the GTPase activity of Cdc42GAP, facilitating the hydrolysis of GTP bound to Cdc42 and thereby, mediating the signaling pathways involving receptor kinases, small GTPases and apoptotic proteins. Nix, which is also designated Nip3L or Bnip3L, is highly related to BNIP-3, and both proteins localize to the mitochondria where they associate with Bcl-2 proteins.
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生物信息学
蛋白别名: Bcl-2 and E1B 19 kDa interacting protein; BCL2/adenovirus E1B 19 kDa protein-interacting protein 2; BCL2/adenovirus E1B 19kDa interacting protein 2; BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP2; BNIP 2
基因别名: BNIP-2; BNIP2; NIP2
UniProt ID: (Human) Q12982
Entrez Gene ID: (Human) 663, (Rat) 300811
apoptotic process
negative regulation of apoptotic process
positive regulation of GTPase activity
positive regulation of muscle cell differentiation
blastocyst development
biological_process
positive regulation of MAPK cascade
positive regulation of neuron differentiation
positive regulation of small GTPase mediated signal transduction
striated muscle cell differentiation
centrosome organization
