Abnova

BNIP3 Polyclonal Antibody, MaxPab™

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BNIP3 Antibody in Western Blot (WB)

BNIP3 Antibody in Western Blot (WB)

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BNIP3 Antibody (H00000664-D01P) in WB

Western Blot analysis of BNIP3 expression in transfected 293T cell line by BNIP3 MaxPab polyclonal antibody. Lane 1: BNIP3 transfected lysate(21.50 KDa). Lane 2: Non-transfected lysate. .

BNIP3 Antibody in Western Blot (WB)

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BNIP3 Antibody in Western Blot (WB) — Western Blot analysis of BNIP3 expression in transfected 293T cell line by BNIP3 MaxPab polyclonal antibody. Lane 1: BNIP3 transfected lysate(21.50 KDa). Lane 2: Non-transfected lysate. .

产品信息

H00000664-D01P

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

BNIP3 (NP_004043.2, 1 a.a. approximately 194 a.a) full-length human protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5-1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Product may be used with Western Blot (Transfected lysate).

The Isotype of this product is composed of an IgG Mixture.

Immunogen sequence: MSQNGAPGMQ EESLQGSWVE LHFSNNGNGG SVPASVSIYN GDMEKILLDA QHESGRSSSK SSHCDSPPRS QTPQDTNRAS ETDTHSIGEK NSSQSEEDDI ERRKEVESIL KKNSDWIWDW SSRPENIPPK EFLFKHPKRT ATLSMRNTSV MKKGGIFSAE FLKVFLPSLL LSHLLAIGLG IYIGRRLTTS TSTF

靶标信息

NIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. NIP3 contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BCL2/adenovirus E1B 19kDa interacting protein 3

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基因别名: BNIP3; NIP3

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UniProt ID: (Human) Q12983

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Entrez Gene ID: (Human) 664

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protein binding identical protein binding protein homodimerization activity protein heterodimerization activity GTPase binding

mitophagy response to hypoxia apoptotic process cell death granzyme-mediated apoptotic signaling pathway positive regulation of autophagy negative regulation of mitochondrial fusion positive regulation of cardiac muscle cell apoptotic process positive regulation of macroautophagy mitochondrial protein catabolic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death positive regulation of protein complex disassembly mitochondrial fragmentation involved in apoptotic process negative regulation of membrane potential regulation of mitochondrial membrane permeability autophagic cell death brown fat cell differentiation neuron apoptotic process defense response to virus response to hyperoxia negative regulation of cell death cellular response to hydrogen peroxide cellular response to mechanical stimulus cellular response to cobalt ion cellular response to hypoxia reactive oxygen species metabolic process positive regulation of mitochondrial fission positive regulation of release of cytochrome c from mitochondria mitochondrial outer membrane permeabilization toxin transport regulation of aerobic respiration intrinsic apoptotic signaling pathway in response to hypoxia negative regulation of reactive oxygen species metabolic process