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Immunogen sequence: RTRKPLEALY GYDYFARTCE KWVDGIRQFK HLPDGNICRH LLPRVQCPAL IVHGEKDPLV PRFHADFIHK HVKGSRLHLM PEG
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 87%.
Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Biphenyl hydrolase-like protein; Biphenyl hydrolase-related protein; Bph-rp; Breast epithelial mucin-associated antigen; MCNAA; Poly(ADP-ribose) glycohydrolase; VACVase; Valacyclovir hydrolase; valacyclovirase
Gene Aliases: BPH-RP; BPHL; MCNAA; PARG; VACVASE
UniProt ID: (Human) Q86WA6
Entrez Gene ID: (Human) 670
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