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Immunogen sequence: SEEVDQELIE DSQWEEILKQ PCPSQYSAIK EEDLVVWVDP LDGTKEYTEG LLDNVTVLIG IAYEGKAIAG VINQPYYNYE AGP
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 92%.
BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 3'(2'),5'-bisphosphate nucleotidase 1; 3'-phosphoadenosine 5'-phosphate phosphatase; Bisphosphate 3'-nucleotidase 1; BPntase; BPntase 1; epididymis luminal protein 20; HsPIP; Inositol-polyphosphate 1-phosphatase; PAP phosphatase; PAP-inositol 1,4-phosphatase; PAP-inositol-1,4-phosphatase; testicular tissue protein Li 29
基因别名: BPNT1; HEL20; PIP
UniProt ID: (Human) O95861
Entrez Gene ID: (Human) 10380