Invitrogen

BRCA2 Polyclonal Antibody

1 Reference
View all (23) BRCA2 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-96128

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
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ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1600 of BRCA2 (NP_0000503)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.17 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2807930

Product Specific Information

Positive Samples: 293T; Cellular Location: Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center

Immunogen sequence: KESFNKIVNF FDQKPEELHN FSLNSELHSD IRKNKMDILS YEETDIVKHK ILKESVPVGT GNQLVTFQGQ PERDEKIKEP TLLGFHTASG KKVKIAKESL DKVKNLFDEK EQGTSEITSF SHQWAKTLKY REACKDLELA CETIEITAAP KCKEMQNSLN N

Target Information

Breast Cancer Type 2 susceptibility protein (BRCA2) is a tumor-suppressor protein reported to be involved in double-strand break repair, homologous recombination and S-phase checkpoint activation.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: brca 2; brca-2; BRCA1/BRCA2-containing complex, subunit 2; breast and ovarian cancer susceptibility gene, early onset; breast and ovarian cancer susceptibility protein 2; breast cancer 2 tumor suppressor; breast cancer 2, early onset; breast cancer 2, mutation 1, University of Wisconsin-Madison; breast cancer susceptibility protein 2; Breast cancer type 2 susceptibility protein; Breast cancer type 2 susceptibility protein homolog; FANCB; Fanconi anemia group D1 protein; Fanconi anemia group D1 protein homolog; mutant BRCA2; RP11-298P3.4

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Gene Aliases: BRCA2; BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD; FANCD1; GLM3; PNCA2; RAB163; XRCC11

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UniProt ID: (Human) P51587, (Mouse) P97929

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Entrez Gene ID: (Human) 675, (Mouse) 12190, (Rat) 360254

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Function(s)
protease binding single-stranded DNA binding histone acetyltransferase activity protein binding H3 histone acetyltransferase activity H4 histone acetyltransferase activity gamma-tubulin binding DNA binding damaged DNA-binding protein
Process(es)
telomere maintenance via recombination double-strand break repair via homologous recombination DNA synthesis involved in DNA repair strand displacement cytokinesis oocyte maturation inner cell mass cell proliferation nucleotide-excision repair double-strand break repair DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator male meiosis I spermatogenesis brain development cell aging response to nutrient female gonad development response to X-ray response to UV-C response to gamma radiation hemopoiesis mammary gland development chromosome breakage homologous chromosome orientation involved in meiotic metaphase I plate congression response to estradiol regulation of cytokinesis negative regulation of mammary gland epithelial cell proliferation multicellular organism growth intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator histone H3 acetylation histone H4 acetylation positive regulation of transcription, DNA-templated positive regulation of mitotic cell cycle replication fork protection centrosome duplication establishment of protein localization to telomere mitotic recombination-dependent replication fork processing DNA repair DNA recombination regulation of transcription, DNA-templated cellular response to DNA damage stimulus cell cycle cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage regulation of cell proliferation chordate embryonic development chromosome organization
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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