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产品信息
PA5-142451
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-PETSNPNKPKRQTNQ.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2933099
产品详细信息
Additional Information: This antibody is expected to recognize both reported isoforms (NP_490597.1; NP_055114.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.
靶标信息
BRD4, a ubiquitously expressed nuclear phosphoprotein, is a member of BET protein family. It is a human homolog of mouse MCAP and consists of 2 N-terminal bromodomains, a central ET-domain, and several kinase-like motifs in its N-terminus. It is expressed as 2 isoforms; the longer variant has a C-terminus region with a praline and glutamine-rich domains. BRD4 is a chromatin-binding protein whose expression is induced in response to growth stimuli. BRD4 acts at different stages of the cell cycle by interacting with proteins including RFC and SPA-1 and regulates cell growth. It also has a role in regulating chromosomal dynamics during mitosis. BRD4 functions as a cellular target for E2 protein of papillomavirus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BRD4-NUT FUSION; bromodomain-containing 5; Bromodomain-containing protein 4; fsh-like protein; MCAP; Mitotic chromosome-associated protein
基因别名: Brd4; Brd5; HUNK1; MCAP; WI-11513
UniProt ID: (Mouse) Q9ESU6
Entrez Gene ID: (Mouse) 57261
regulation of transcription involved in G1/S transition of mitotic cell cycle
inner cell mass cell proliferation
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
chromosome segregation
positive regulation of G2/M transition of mitotic cell cycle
chromatin modification
positive regulation of transcription elongation from RNA polymerase II promoter
positive regulation of DNA binding
histone H4-K12 acetylation
histone H3-K14 acetylation
