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BRUCE Antibody (PA5-114907) in IHC (P)
Immunohistochemistry analysis of BRUCE in human colorectal cancer. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-114907) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
产品信息
PA5-114907
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human BIRC6(Accession Q9NR09), corresponding to amino acid residues L4692-E4742.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899543
产品详细信息
Antibody detects endogenous levels of total BIRC6.
靶标信息
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: APOLLON; baculoviral IAP repeat-containing 6; Baculoviral IAP repeat-containing protein 6; baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; accccbaculoviral IAP repeat-containing 6; BIR repeat-containing ubiquitin-conjugating enzyme; BRUCE; RING-type E3 ubiquitin transferase BIRC6; Ubiquitin-conjugating BIR domain enzyme apollon; ubiquitin-conjugating BIR-domain enzyme apollon
基因别名: A430032G04Rik; A430040A19Rik; AA501170; APOLLON; BIRC6; BRUCE; D630005A10Rik; KIAA1289; mKIAA1289
UniProt ID: (Human) Q9NR09, (Mouse) O88738
Entrez Gene ID: (Human) 57448, (Mouse) 12211
ubiquitin-protein transferase activity
cysteine-type endopeptidase inhibitor activity
protein binding
ligase activity
ubiquitin conjugating enzyme activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
peptidase inhibitor activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
protein phosphorylation
apoptotic process
mitotic nuclear division
positive regulation of cell proliferation
negative regulation of endopeptidase activity
protein ubiquitination
regulation of cytokinesis
regulation of cell proliferation
negative regulation of apoptotic process
cell division
labyrinthine layer development
spongiotrophoblast layer development
negative regulation of extrinsic apoptotic signaling pathway
placenta development
cell cycle
regulation of signal transduction
negative regulation of peptidase activity
