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BTBD12 Antibody (H00084464-B01P) in WB
Western Blot analysis of BTBD12 expression in transfected 293T cell line (H00084464-T02) by BTBD12 MaxPab polyclonal antibody.
Lane 1: BTBD12 transfected lysate(126.61 KDa).
Lane 2: Non-transfected lysate.
Lane 1: BTBD12 transfected lysate(126.61 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00084464-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
BTBD12 (AAH36335.1, 1 a.a. approximately 1151 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MVNNPHLSDV QFQTDSGEVL YAHKFVLYAR CPLLIQYVNN EGFSAVEDGV LTQRVLLGDV STEAARTFLH YLYTADTGLP PGLSSELSSL AHRFGVSELV HLCEQVPIAT DSEGKPWEEK EAENCESRAE NFQELLRSMW ADEEEEAETL LKSKDHEEDQ ENVNEAEMEE IYEFAATQRK LLQEERAAGA GEDADWLEGG SPVSGQLLAG VQVQKQWDKV EEMEPLEPGR DEAATTWEKM GQCALPPPQG QHSGARGAEA PEQEAPEEAL GHSSCSSPSR DCQAERKEGS LPHSDDAGDY EQLFSSTQGE ISEPSQITSE PEEQSGAVRE RGLEVSHRLA PWQASPPHPC RFLLGPPQGG SPRGSHHTSG SSLSTPRSRG GTSQVGSPTL LSPAVPSKQK RDRSILTLSK EPGHQKGKER RSVLECRNKG VLMFPEKSLS IDLTQSNPDH SSSRSQKSSS KLNEEDEVIL LLDSDEELEL EQTKMKSISS DPLEEKKALE ISPRSCELFS IIDVDADQEP SQSPPRSEAV LQQEDEGALP ENRGSLGRRG APWLFCDRES SPSEASTTDT SWLVPATPLA SRSRDCSSQT QISSLRSGLA VQAVTQHTPR ASVGNREGNE VAQKFSVIRP QTPPPQTPSS CLTPVSPGTS DGRRQGHRSP SRPHPGGHPH SSPLAPHPIS GDRAHFSRRF LKHSPPGPSF LNQTPAGEVV EVGDSDDEQE VASHQANRSP PLDSDPPIPI DDCCWHMEPL SPIPIDHWNL ERTGPLSTSS PSRRMNEAAD SRDCRSPGLL DTTPIRGSCT TQRKLQEKSS GAGSLGNSRP SFLNSALWDV WDGEEQRPPE TPPPAQMPSA GGAQKPEGLE TPKGANRKKN LPPKVPITPM PQYSIMETPV LKKELDRFGV RPLPKRQMVL KLKEIFQYTH QTLDSDSEDE SQSSQPLLQA PHCQTLASQT YKPSRAGVHA QQEATTGPGA HRPKGPAKTK GPRHQRKHHE SITPPSRSPT KEAPPGLNDD AQIPASQESV ATSVDGSDSS LSSQSSSSCE FGAAFESAGE EEGEGEVSAS QAAVQAADTD EALRCYIRSK PALYQKVLLY QPFELRELQA ELRQNGLRVS SRRLLDFLDT HCITFTTAAT RREKLQGRRR QPRGKKKVER N
靶标信息
This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BTB (POZ) domain containing 12; BTB/POZ domain-containing protein 12; SLX4 structure-specific endonuclease subunit homolog; Structure-specific endonuclease subunit SLX4
基因别名: BTBD12; FANCP; KIAA1784; KIAA1987; MUS312; SLX4
UniProt ID: (Human) Q8IY92
Entrez Gene ID: (Human) 84464
double-strand break repair via homologous recombination
DNA replication
DNA repair
nucleotide-excision repair
DNA double-strand break processing involved in repair via single-strand annealing
interstrand cross-link repair
positive regulation of catalytic activity
response to intra-S DNA damage checkpoint signaling
t-circle formation
positive regulation of t-circle formation
