Bethyl Laboratories

BTBD12 Polyclonal Antibody

BTBD12 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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BTBD12 Antibody (IHC-00643) in IHC (P)

Detection of human BTBD12 by immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-BTBD12 (Product # IHC-00643) used at a dilution of 1:250. Detection: DAB.

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产品信息

IHC-00643

应用

建议稀释比

已发表文章

免疫组化 (IHC)

1:100-1:500

免疫组化（石蜡） (IHC (P))

1:100-1:500

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Region between residue 1784 to 1834 of human BTB (POZ) domain containing 12.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.25 mg/mL

纯化类型

Antigen affinity chromatography

保存液

TBS, pH 7.0 to 8.0, with 0.1% BSA

内含物

0.09% sodium azide

保存条件

4° C

运输条件

Wet ice

产品详细信息

The recommended shelf life for this product is 1 year from date of receipt.

Based on 100% sequence identity, this antibody is predicted to react with Gorilla and Chimpanzee

靶标信息

This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: BTB (POZ) domain containing 12; BTB/POZ domain-containing protein 12; SLX4 structure-specific endonuclease subunit homolog; Structure-specific endonuclease subunit SLX4

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基因别名: BTBD12; FANCP; KIAA1784; KIAA1987; MUS312; SLX4

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UniProt ID: (Human) Q8IY92

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Entrez Gene ID: (Human) 84464

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功能

endodeoxyribonuclease activity protein binding enzyme activator activity crossover junction endodeoxyribonuclease activity 5'-flap endonuclease activity 3'-flap endonuclease activity

参与通路

double-strand break repair via homologous recombination DNA replication DNA repair nucleotide-excision repair DNA double-strand break processing involved in repair via single-strand annealing interstrand cross-link repair positive regulation of catalytic activity response to intra-S DNA damage checkpoint signaling t-circle formation positive regulation of t-circle formation