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产品信息
PA5-45039
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal of human BTBD12 (aa 100-149).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2606802
产品详细信息
Peptide sequence: TKTLQGPAEK KPPSGSQAPR TKKQRVTKWQ ASEPAHSVNG EGGVLASAPD
Sequence homology: Human: 100%; Rabbit: 91%
靶标信息
This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BTB (POZ) domain containing 12; BTB/POZ domain-containing protein 12; SLX4 structure-specific endonuclease subunit homolog; Structure-specific endonuclease subunit SLX4
基因别名: BTBD12; FANCP; KIAA1784; KIAA1987; MUS312; SLX4
UniProt ID: (Human) Q8IY92
Entrez Gene ID: (Human) 84464
double-strand break repair via homologous recombination
DNA replication
DNA repair
nucleotide-excision repair
DNA double-strand break processing involved in repair via single-strand annealing
interstrand cross-link repair
positive regulation of catalytic activity
response to intra-S DNA damage checkpoint signaling
t-circle formation
positive regulation of t-circle formation
