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Product Details
BAB-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
N-epitope Synthetic peptide corresponding to amino acid region 200-221 of Drosophila melanogaster protein. The peptide was covalently modified for conjugation.Synthetic peptide:CNKNENMKRIFEDYVPHRLTS
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Invovled in activin binding, GPCR kinase activity, serine threonine kinase activity and transforming growth factor beta receptor activity. The role of Baboon (Babo), a type I Activin receptor previously called Atr-I, in Drosophila development and characterize aspects of the Babo intracellular signal-transduction pathway. Genetic analysis of babo loss-of-function mutants and ectopic activation studies indicate that Babo signaling plays a role in regulating cell proliferation. In mammalian cells, activated Babo specifically stimulates Smad2-dependent pathways to induce TGF-beta/Activin-responsive promoters but not BMP-responsive elements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor 45A; activin type I receptor; babo; babo-PA; babo-PB; babo-PC; baboa; CG8224; CG8224-PA; CG8224-PB; CG8224-PC; G protein-coupled receptor kinase 3; RE55648p; Receptor protein serine/threonine kinase
Gene Aliases: Atf1; ATR-1; ATR-I; Atr45A; AtrI; Bab; BABO; Babo-a; BaboA; CG8224; Dmel\CG8224; Dmel_CG8224; Gprk-3; Gprk3; l(2)44Fd; l(2)k16912; STK-E
Entrez Gene ID: (Fruit fly) 35900
positive regulation of neuroblast proliferation
protein phosphorylation
nervous system development
axon guidance
eye-antennal disc morphogenesis
imaginal disc-derived wing morphogenesis
determination of adult lifespan
response to UV
negative regulation of autophagy
mushroom body development
activin receptor signaling pathway
glucose homeostasis
regulation of imaginal disc-derived wing size
R8 cell fate specification
positive regulation of imaginal disc growth
neuron development
dendrite morphogenesis
regulation of synapse structure or activity
pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
cellular response to glucose stimulus
cellular response to growth factor stimulus
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