Invitrogen

Bcl-W Monoclonal Antibody (F.584.7)

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Bcl-W Antibody (MA5-15076) in WB

Western blot analysis of Bcl-w in extracts from A673 and C2C12 cell lines using Bcl-w monoclonal antibody (Product # MA5-15076).

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产品信息

MA5-15076

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Monoclonal

类型

Antibody

克隆号

F.584.7

抗原

Synthetic peptide corresponding to residues surrounding alanine 39 of Bcl-w

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

107 µg/mL

纯化类型

Affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

<0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_10983656

产品详细信息

It is not recommended to aliquot this antibody.

靶标信息

Using a PCR-based strategy, an additional protein with life-promoting activity, designated Bcl-w, has been identified. The protein is highly conserved between mouse and human and is encoded by a gene located near the TCRalpha gene on chromosome 14. Bcl-w is expressed in myeloid cell lines but not in T and B lymphocytes, and can be found in a wide range of tissues. An alternative splicing event in exon 4 results in two transcripts. The first, Bcl-w, encodes a protein of 193 amino acids, and the second, Bcl-w/rox, encodes a protein 333 amino acids in length. The "rox" portion of Bcl-w/rox shows a striking 66% amino acid sequence identity with the Drosophila rox2 protein; however, the Bcl-w/rox transcript may be expressed at very low levels.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Noxa and Mcl-1 expression influence the sensitivity to BH3-mimetics that target Bcl-xL in patient-derived glioma stem cells.

Scientific reports

Vera MB,Morris-Hanon O,Nogueiras GI,Ripari LB,Esquivel MI,Perez-Castro C,Romorini L,Sevlever GE,Scassa ME,Videla-Richardson GA

MA5-15076 was used in Western Blotting to determine that the most abundantly expressed anti-apoptotic Bcl-2 family members, Bcl-xL and Mcl-1, are the most relevant in regulating patient-derived glioma stem cell survival.

Sat Oct 22 00:00:00 UTC 2022

Noxa and Mcl-1 expression influence the sensitivity to BH3-mimetics that target Bcl-xL in patient-derived glioma stem cells.

Scientific reports

Vera MB,Morris-Hanon O,Nogueiras GI,Ripari LB,Esquivel MI,Perez-Castro C,Romorini L,Sevlever GE,Scassa ME,Videla-Richardson GA

Sat Oct 22 00:00:00 UTC 2022

In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome.

Journal of psychopharmacology (Oxford, England)

Naert G,Ferré V,Keller E,Slender A,Gibbins D,Fisher EM,Tybulewicz VL,Maurice T

Published figure using Bcl-W monoclonal antibody (Product # MA5-15076) in Western Blot

Thu Feb 01 00:00:00 UTC 2018

生物信息学

蛋白别名: Apoptosis regulator Bcl-W; Bcl-2-like protein 2; Bcl2-L-2; BCL2-like 2 protein; Bcl2-like protein 2; c98; protein phosphatase 1, regulatory subunit 51

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基因别名: AW048834; BCL-W; BCL-WEL; BCL-WS; BCL2-L-2; BCL2L2; BCLW; c98; Gtrgal2; Gtrosa41; KIAA0271; PPP1R51

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UniProt ID: (Human) Q92843, (Mouse) P70345

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Entrez Gene ID: (Human) 599, (Mouse) 12050, (Rat) 60434

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功能

protein binding protein homodimerization activity protein heterodimerization activity BH domain binding

参与通路

spermatogenesis intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of apoptotic process Sertoli cell proliferation extrinsic apoptotic signaling pathway in absence of ligand negative regulation of intrinsic apoptotic signaling pathway apoptotic process regulation of apoptotic process