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Beta-2-adaptin Antibody (A304-719A) in WB
Detection of mouse Beta-2-adaptin by western blot. Samples: Whole cell lysate (25 µg) from NIH 3T3, CH27, BW5147.3, CT26, and TCMK-1 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-Beta-2-adaptin antibody (Product # A304-719A lot 2) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 10 seconds.
产品信息
A304-719A
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 575 to 625 of human Beta-2-adaptin.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
phosphate/tris citrate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Rat and Bovine
靶标信息
Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate ~100 kDa gene products with similar domain structures (alpha and beta adaptin) and a ~50 and ~17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adapter-related protein complex 2 beta subunit; adapter-related protein complex 2 subunit beta; adaptin, beta 2 (beta); Adaptor protein complex AP-2 subunit beta; adaptor related protein complex 2, beta 1 subunit; Adaptor-related protein complex 2 subunit beta; adaptor-related protein complex 2, beta 1 subunit; AP-2 complex subunit beta; AP105B; Beta-2-adaptin; Beta-adaptin; beta2-adaptin; Clathrin assembly protein complex 2 beta large chain; clathrin-associated/assembly/adaptor; clathrin-associated/assembly/adaptor protein, large, beta 1; Plasma membrane adaptor HA2/AP2 adaptin beta subunit; testicular tissue protein Li 22
基因别名: 1300012O03Rik; ADTB2; AI788979; AP105B; AP2-BETA; AP2B1; CLAPB1
UniProt ID: (Human) P63010, (Mouse) Q9DBG3
Entrez Gene ID: (Human) 163, (Mouse) 71770
ventricular septum development
intracellular protein transport
microtubule-based movement
antigen processing and presentation of exogenous peptide antigen via MHC class II
aorta development
negative regulation of epidermal growth factor receptor signaling pathway
ephrin receptor signaling pathway
clathrin coat assembly
regulation of defense response to virus by virus
Wnt signaling pathway, planar cell polarity pathway
coronary vasculature development
clathrin-mediated endocytosis
transport
endocytosis
protein transport
vesicle-mediated transport
