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产品信息
PA5-82588
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2789745
产品详细信息
Immunogen sequence: MNIFDRKINF DALLKFSHIT PSTQQHLKK
靶标信息
BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007). BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli. Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress-causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury. Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, itis thought to involve regulation of Ca2+ handling by the ER.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bax inhibitor 1; BI-1; testis enhanced gene transcript; Testis-enhanced gene transcript protein; Transmembrane BAX inhibitor motif-containing protein 6
基因别名: BAXI1; BI-1; BI1; TEGT; TMBIM6
UniProt ID: (Human) P55061
Entrez Gene ID: (Human) 7009
autophagy
response to unfolded protein
spermatogenesis
lung development
negative regulation of protein binding
endoplasmic reticulum calcium ion homeostasis
negative regulation of apoptotic process
negative regulation of immunoglobulin secretion
negative regulation of endoribonuclease activity
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
response to L-glutamate
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
negative regulation of apoptotic signaling pathway
