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产品信息
PA5-17327
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues within a central region of Bit1
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10981292
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency. Alternative splicing results in multiple transcript variants encoding different isoforms.
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生物信息学
蛋白别名: Bcl-2 inhibitor of transcription 1; cilia and flagella associated protein 37; OTTHUMP00000205936; Peptidyl-tRNA hydrolase 2, mitochondrial; PTH 2
基因别名: BIT1; CFAP37; CGI-147; IMNEPD; PTH; PTH 2; PTH2; PTRH2
UniProt ID: (Human) Q9Y3E5
Entrez Gene ID: (Human) 51651
