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产品信息
MA5-38134
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC1983
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 266-435 of human Brachyury (O15178)
偶联物
形式
Liquid
浓度
0.78 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2898052
产品详细信息
Positive Samples: NCI-H460, Mouse brain, Mouse thymus, Rat brain
Immunogen sequence: GALSLPSTHS CDRYPTLRSH RSSPYPSPYA HRNNSPTYSD NSPACLSMLQ SHDNWSSLGM PAHPSMLPVS HNASPPTSSS QYPSLWSVSN GAVTPGSQAA AVSNGLGAQF FRGSPAHYTP LTHPVSAPSS SGSPLYEGAA AATDIVDSQY DAAAQGRLIA SWTPVSPPSM
靶标信息
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: brachyury homolog; Brachyury protein; brachyury-like 2; brachyury-like 3; low ratio; Protein T; RP11-459F1.1; T brachyury homolog; T, brachyury homolog; T-box transcription factor T
基因别名: Bra; cou; D17Mit170; Low; Lr; me75; SAVA; T; T1; TBXT; TFT; Tl2; Tl3
UniProt ID: (Human) O15178, (Mouse) P20293
Entrez Gene ID: (Human) 6862, (Rat) 292301, (Mouse) 20997
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor binding
RNA polymerase II activating transcription factor binding
transcriptional repressor activity, RNA polymerase II transcription factor binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
molecular_function
sequence-specific DNA binding
DNA binding
protein binding
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
somitogenesis
neural plate morphogenesis
neural tube closure
heart morphogenesis
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
transcription, DNA-templated
signal transduction
penetration of zona pellucida
mesoderm development
mesoderm migration involved in gastrulation
positive regulation of cell proliferation
anterior/posterior axis specification, embryo
notochord formation
signal transduction involved in regulation of gene expression
BMP signaling pathway
post-anal tail morphogenesis
embryonic skeletal system development
canonical Wnt signaling pathway
bone morphogenesis
SMAD protein signal transduction
determination of heart left/right asymmetry
cellular response to retinoic acid
primitive streak formation
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
anatomical structure morphogenesis
anterior/posterior pattern specification
reproductive process
notochord development
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
multicellular organism development
cardiac muscle cell differentiation
