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产品信息
MA1-825
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse,
Non-human primate
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
15C8
抗原
Synthetic peptide corresponding to residues M(1) E S A D F Y E V E P R P P(14) of mouse C/EBP alpha.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2077903
产品详细信息
MA1-825 detects C/EBP alpha protein in human, mouse and rat samples.
MA1-825 has successfully been used in Western blot and immunoprecipitation procedures. By Western blot, this antibody detects a 45 kDa protein representing C/EBP alpha in transfected hu293T cells. MA1-825 is specific to the amino terminal region of C/EBP alpha.
The MA1-825 immunogen is a synthetic peptide corresponding to residues M(1) E S A D F Y E V E P R P P(14) of mouse C/EBP alpha. This peptide (Cat. # PEP-242) is available for use in neutralization and control experiments.
靶标信息
The C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP. One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation. From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: C EBP; C/EBP alpha; CAAT/enhancer-binding protein DNA-binding protein; CAAT/enhancer-binding protein, DNA-binding protein; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer binding protein, alpha; CCAAT/enhancer-binding protein alpha; OTTHUMP00000220269
基因别名: C/EBP-alpha; C/ebpalpha; CBF-A; CEBP; CEBPA; DBPCEP
UniProt ID: (Human) P49715, (Mouse) P53566, (Rat) P05554
Entrez Gene ID: (Human) 1050, (Mouse) 12606, (Rat) 24252
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
protein binding
transcription factor binding
kinase binding
protein homodimerization activity
transcription regulatory region DNA binding
RNA polymerase I regulatory region DNA binding
protein domain specific binding
protein complex binding
histone deacetylase binding
sequence-specific DNA binding
protein heterodimerization activity
HMG box domain binding
urea cycle
negative regulation of transcription from RNA polymerase II promoter
liver development
embryonic placenta development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase I promoter
transcription from RNA polymerase II promoter
mitochondrion organization
Notch signaling pathway
multicellular organism development
cholesterol metabolic process
negative regulation of cell proliferation
cytokine-mediated signaling pathway
myeloid cell differentiation
macrophage differentiation
lung development
granulocyte differentiation
regulation of cell proliferation
glucose homeostasis
fat cell differentiation
positive regulation of fat cell differentiation
positive regulation of osteoblast differentiation
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase III promoter
cell maturation
inner ear development
white fat cell differentiation
brown fat cell differentiation
lipid homeostasis
cellular response to lithium ion
cellular response to organic cyclic compound
generation of precursor metabolites and energy
viral process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of cyclin-dependent protein serine/threonine kinase activity
acute-phase response
response to nutrient
cell differentiation
organ regeneration
response to vitamin B2
response to glucocorticoid
