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Product Details
PA5-37975
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-TANQVKIYTNQEKT, from the internal region of C16orf57 (aa154-167)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2554579
Product Specific Information
This antibody is expected to recognize both reported isoforms (NP_078874.2; NP_001182231.1).
It is predicted to react with pig based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
C16orf57 is a phosphodiesterase responsible for the U6 snRNA 3' end processing. This protein acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3'-5' RNA exonuclease USB1; FLJ13154; hUsb1; HVSL motif containing 1; Mutated in PN protein 1; Mutated in poikiloderma with neutropenia protein 1; putative U6 snRNA phosphodiesterase; U six biogenesis 1; U6 snRNA biogenesis 1; U6 snRNA phosphodiesterase; U6 snRNA phosphodiesterase 1; U6 snRNA phosphodiesterase {ECO:0000255|HAMAP-Rule:MF_03040}; UPF0406 protein C16orf57; UPF0406 protein C16orf57 homolog; USB1
Gene Aliases: AA960436; C16orf57; hUsb1; HVSL1; Mpn1; PN; RGD1305215; USB1
UniProt ID: (Human) Q9BQ65, (Mouse) Q91W78, (Rat) Q5I0I5
Entrez Gene ID: (Human) 79650, (Mouse) 101985, (Rat) 307643
3'-5'-exoribonuclease activity
cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
photoreceptor cyclic-nucleotide phosphodiesterase activity
nuclease activity
hydrolase activity
7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity
inositol phosphosphingolipid phospholipase activity
inositol phosphorylceramide phospholipase activity
mannosyl-inositol phosphorylceramide phospholipase activity
mannosyl-diinositol phosphorylceramide phospholipase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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