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产品信息
PA5-52633
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2638839
产品详细信息
Immunogen sequence: LRVSVKAEAP AGPALGLPSP EAESGVDRGE PEPMEVEEGE LEIVPVRRSL KELIPDTSRR YENKAGSFIT GIDVTSKEAI EKKEQRAKRF HFRSEVNLAQ RNVALDRDMM KKAIPKVRLE TIYICGVD
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
靶标信息
Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CTD-3195I5.1; CTD-3195I5.5; Nuclear cap-binding protein subunit 3; Protein ELG
基因别名: C17orf85; ELG; HSA277841; NCBP3
UniProt ID: (Human) Q53F19
Entrez Gene ID: (Human) 55421
