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产品信息
H00114897-M01
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4A10
抗原
C1QTNF1 (AAH21553.1, 26 a.a. approximately 281 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: RVPHVQGEQQ EWEGTEELPS PPDHAERAEE QHEKYRPSQD QGLPASRCLR CCDPGTSMYP ATAVPQINIT ILKGEKGDRG DRGLQGKYGK TGSAGARGHT GPKGQKGSMG APGERCKSHY AAFSVGRKKP MHSNHYYQTV IFDTEFVNLY DHFNMFTGKF YCYVPGLYFF SLNVHTWNQK ETYLHIMKNE EEVVILFAQV GDRSIMQSQS LMLELREQDQ VWVRLYKGER ENAIFSEELD TYITFSGYLV KHATEP
靶标信息
Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. In obese (ob/ob) mice, RT-PCR analysis showed that mCTRP1 transcripts are seen at substantially higher levels in adipose tissues compared to those of normal mice.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Complement C1q tumor necrosis factor-related protein 1; G protein coupled receptor interacting protein; G protein-coupled receptor-interacting protein; GIP; Putative secreted protein ZSIG37
基因别名: 1600017K21Rik; C1QTNF1; CTRP1; GIP; UNQ310/PRO353; ZSIG37
UniProt ID: (Human) Q9BXJ1, (Mouse) Q9QXP7, (Rat) Q5XIG2
Entrez Gene ID: (Human) 114897, (Mouse) 56745, (Rat) 303701
positive regulation of cytosolic calcium ion concentration
negative regulation of platelet activation
positive regulation of gene expression
regulation of glucose metabolic process
positive regulation of MAPK cascade
protein homooligomerization
positive regulation of protein kinase B signaling
protein heterotrimerization
negative regulation of platelet aggregation
positive regulation of aldosterone secretion
