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C1orf77 Antibody (PA5-44307) in IHC
Immunofluorescent analysis of C1orf77 (red) and Insulin (green) were performed on mouse pancreatic tissue from NOD (Non-obese diabetic) mice and CD1 (cluster of differentiation 1) mice. To expose target proteins, antigen retrieval was performed by microwaving tissues for three times with each 5 minutes in 10mM sodium citrate buffer (pH 6.0). Following antigen retrieval slides were wash with PBS and PBS+1% lamb serum, and then the slides were blocked with 1:50 normal donkey serum for 30 min at room temperature. The tissues were probed for C... View More
产品信息
PA5-44307
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the middle region of human C1orf77
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2576376
产品详细信息
Peptide sequence: LKQSLKQRLG KSNIQARLGR PIGALARGAI GGRGLPIIQR GLPRGGLRGG
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
PA5-44307 detects C1orf77 in IF application with mouse samples.
靶标信息
CHTOP is a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Chromatin target of PRMT1 protein; DKFZP547E1010; Friend of Prmt1; Friend of PRMT1 protein; RP1-178F15.2; Small arginine- and glycine-rich protein; small protein rich in arginine and glycine; SRAG
基因别名: 2500003M10Rik; C1orf77; CHTOP; FL-SRAG; FOP; HT031; MNCb-1706; PP7704; SRAG; SRAG-3; SRAG-5
UniProt ID: (Human) Q9Y3Y2, (Mouse) Q9CY57
Entrez Gene ID: (Human) 26097, (Mouse) 66511
regulation of transcription, DNA-templated
termination of RNA polymerase II transcription
RNA export from nucleus
mRNA export from nucleus
positive regulation of cell proliferation
positive regulation of histone methylation
mRNA 3'-end processing
positive regulation of ATPase activity
positive regulation of helicase activity
transcription, DNA-templated
