Invitrogen

C4BPA Polyclonal Antibody

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C4BPA Antibody (PA5-76234) in WB

Western blot was performed using Anti-C4BPA Polyclonal Antibody (Product # PA5-76234) and bands corresponding to 93 kDa and 52 kDa of C4BPA was observed in the reported positive models- Hep G2 and Mouse Epididymis relative to DU 145, BeWO and Mouse Lung which are low expressing models along with an uncharacterized band (*) at ~40 kDa in the cell lines tested. Whole cell extracts (30 µg lysate) of Hep G2 (Lane 1), DU 145 (Lane 2), BeWO (Lane 3), tissue extracts (30 µg lysate) of Mouse Lungs (Lane 4) and Mouse Epididymis (Lane 5) were electr... View More

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产品信息

PA5-76234

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

免疫组化 (IHC)

1:50-1:100

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide of human C4BPA.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2719961

产品详细信息

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

靶标信息

There are 3 variants of Complement component 4 binding protein (C4bp), which is composed of alpha and beta chains. The predominant form is a 570 kDa complex of 7 alpha chains and 1 beta chain. The other complexes formed are a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. C4bp regulates the activation of the classical complement pathway. It is a cofactor to the C3b/C4b inactivator, crucial to the proteolytic cleavage of C4b and important in cleavage of C3b. C4bp also regulates the C4bC2a complex (C3 convertase), accelerating its degradation by dissociating the complement fragment C2a. Both the C4bp alpha and beta chains interact with anticoagulant protein S and C4bp alpha binds protein S. C4bp is expressed in the blood serum.

仅用于科研。不用于诊断过程。未经明确授权不得转售。