Rockland

C9orf72 Polyclonal Antibody

产品信息

200-901-MH2

应用

建议稀释比

已发表文章

免疫组化 (IHC)

1:200

流式细胞分析 (Flow)

1:20

酶联免疫吸附实验 (ELISA)

1:10,000-1:50,000

产品规格

种属反应

Human

宿主/亚型

Chicken / IgY

分类

Polyclonal

类型

Antibody

抗原

Anti-C9orf72 antibody was prepared from eggs of chickens laid after repeated immunizations with a synthetic peptide corresponding to a C-terminal portion of human C9orf72 surrounding aa 425-481 conjugated to Keyhole Limpet Hemocyanin (KLH).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.03 mg/mL

纯化类型

selective precipitation

保存液

PBS, pH 7

内含物

0.01% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

This affinity purified antibody is directed against human C9orf72. This product is an IgY fraction antibody purified from monospecific chicken egg yolks by a multi-step process which includes selective precipitation and salt fractionation followed by extensive dialysis against the buffer stated above.A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to mouse and rat.

靶标信息

C9orf72 may play a role in endosomal trafficking and autophagy. It is known to interact with HNRNPA1, HNRNPA2B1, UBQLN2, and small Rab GTPSases. C9orf72 localizes in the nucleus, cytoplasm, endosome, lysosome, and autophagosome. Mutations in this gene can result in frontotemporal dementia and/or amyotrophic lateral sclerosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。