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产品信息
PA5-95694
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-341 of human CAB39 (NP_0573731)
偶联物
形式
Liquid
浓度
1.16 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807496
产品详细信息
Positive Samples: U-87MG; Cellular Location: Cytoplasm
Immunogen sequence: MPFPFGKSHK SPADIVKNLK ESMAVLEKQD ISDKKAEKAT EEVSKNLVAM KEILYGTNEK EPQTEAVAQL AQELYNSGLL STLVADLQLI DFEGKKDVAQ IFNNILRRQI GTRTPTVEYI CTQQNILFML LKGYESPEIA LNCGIMLREC IRHEPLAKII LWSEQFYDFF RYVEMSTFDI ASDAFATFKD LLTRHKLLSA EFLEQHYDRF FSEYEKLLHS ENYVTKRQSL KLLGELLLDR HNFTIMTKYI SKPENLKLMM NLLRDKSRNI QFEAFHVFKV FVANPNKTQP ILDILLKNQA KLIEFLSKFQ NDRTEDEQFN DEKTYLVKQI RDLKRPAQQE A
靶标信息
Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha). STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: calcium binding protein, 39 kDa; Calcium-binding protein 39; MO25alpha; Protein Mo25
基因别名: AA408805; AA960512; C78372; CAB39; CGI-66; MO25; MO25alpha
UniProt ID: (Human) Q9Y376, (Mouse) Q06138
Entrez Gene ID: (Human) 51719, (Rat) 301574, (Mouse) 12283
cell cycle arrest
positive regulation of peptidyl-threonine phosphorylation
peptidyl-serine phosphorylation
signal transduction by protein phosphorylation
activation of protein kinase activity
intracellular signal transduction
protein heterooligomerization
cellular hypotonic response
positive regulation of protein serine/threonine kinase activity
negative regulation of potassium ion transmembrane transporter activity
negative regulation of potassium ion transmembrane transport
negative regulation of rubidium ion transport
negative regulation of rubidium ion transmembrane transporter activity
peptidyl-threonine phosphorylation
positive regulation of peptidyl-serine phosphorylation
