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产品信息
OSC00079W-100UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from aa region 1000-1050 of human CACNA1A conjugated to blue carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen shares 87% identity with mouse and rat sequence.
Specificity of this antibody: CACNA1A.
靶标信息
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the n-repeats occur in the 3 UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the n-repeats which encode a polyglutamine tract. Expansion of the n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BI; brain calcium channel 1; Brain calcium channel I; calcium channel, L type, alpha-1 polypeptide; Calcium channel, L type, alpha-1 polypeptide isoform 4; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; fetal brain Ca2+ voltage-gated channel alpha1A pore-forming subunit; Voltage-dependent P/Q-type calcium channel subunit alpha-1A; Voltage-gated calcium channel subunit alpha Cav2.1
基因别名: APCA; BI; CACH4; CACN3; CACNA1A; CACNL1A4; CAV2.1; EA2; FHM; HPCA; MHP; MHP1; SCA6
UniProt ID: (Human) O00555
Entrez Gene ID: (Human) 773
sulfur amino acid metabolic process
glucose metabolic process
positive regulation of cytosolic calcium ion concentration
gamma-aminobutyric acid signaling pathway
neuromuscular synaptic transmission
synapse assembly
adult walking behavior
cell death
gamma-aminobutyric acid secretion
regulation of acetylcholine secretion, neurotransmission
cell growth
regulation of calcium ion-dependent exocytosis
transmission of nerve impulse
spinal cord motor neuron differentiation
cerebellum maturation
cerebellar molecular layer development
cerebellar Purkinje cell differentiation
vestibular nucleus development
cellular chloride ion homeostasis
negative regulation of hormone biosynthetic process
regulation of ion transmembrane transport
synaptic transmission, glutamatergic
neurotransmitter metabolic process
hormone metabolic process
receptor clustering
negative regulation of neuron apoptotic process
behavioral response to pain
calcium ion-regulated exocytosis of neurotransmitter
dendrite morphogenesis
regulation of axonogenesis
regulation of insulin secretion
musculoskeletal movement, spinal reflex action
neuromuscular process controlling balance
membrane depolarization
rhythmic synaptic transmission
calcium ion transmembrane transport
membrane depolarization during action potential
