Osenses

CACNA1H, CACNA1G Polyclonal Antibody

产品信息

OSC00114G-500UG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

10-50 µg/mL

免疫组化 (IHC)

10-50 µg/mL

其他PubMed (Misc)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Not Applicable

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide from aa region 400-450 of human CACNA1G conjugated to blue carrier protein was used as the antigen

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

Conc. Not Determined

纯化类型

Ammonium sulfate precipitation

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.

The antigen shares 95% identity with the corresponding sequences in rat and mouse.

Specificity of this antibody: CACNA1H and CACNA1G.

靶标信息

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. There are 2 isoforms of CACNA1H and 14 isoforms if CACNA1G, produced by alternative splicing.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

Cell

Olsen JV,Blagoev B,Gnad F,Macek B,Kumar C,Mortensen P,Mann M

Fri Nov 03 00:00:00 UTC 2006

Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family.

Circulation research

Cribbs LL,Lee JH,Yang J,Satin J,Zhang Y,Daud A,Barclay J,Williamson MP,Fox M,Rees M,Perez-Reyes E

Mon Jul 13 00:00:00 UTC 1998

生物信息学

蛋白别名: calcium channel alpha13.2 subunit; calcium channel, voltage-dependent, T type, alpha 1G subunit; calcium channel, voltage-dependent, T type, alpha 1H subunit; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; Cav3.1c; Low-voltage-activated calcium channel alpha1 3.2 subunit; low-voltage-activated calcium channel alpha13.2 subunit; NBR13; T-type Cav3.2; voltage dependent t-type calcium channel alpha-1H subunit; voltage-dependent calcium channel alpha 1G subunit, isoform 11; voltage-dependent T-type calcium channel alpha 1G subunit; Voltage-dependent T-type calcium channel subunit alpha-1G; Voltage-dependent T-type calcium channel subunit alpha-1H; voltage-gated calcium channel alpha subunit Cav3.2; voltage-gated calcium channel alpha subunit CavT.2; Voltage-gated calcium channel subunit alpha Cav3.1; Voltage-gated calcium channel subunit alpha Cav3.2

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基因别名: [a]1G; a1G; alpha-1G; alpha13.2; Ca(V)T.1; CACNA1G; CACNA1H; CACNA1HB; Cav3.1; Cav3.1d; Cav3.2; ECA6; EIG6; KIAA1123; mKIAA1123; MNCb-1209; NBR13; SCA42

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UniProt ID: (Human) O43497, (Human) O95180, (Rat) Q9EQ60