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产品信息
OSC00089W-100UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from a cytoplasmic domain of human CACNA1I (Cav3.3) conjugated to an immunogenic carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and mouse.
Specificity of this antibody: CACNA1I.
靶标信息
CaV3.3 encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by CaV3.3 is characterized by a slower activation and inactivation compared to other T-type calcium channels. CaV3.3 may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants of CaV3.3. Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarization, an proteins such as CaV3.3 regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression. Diseases associated with CACNA1I include Childhood Absence Epilepsy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Ca(v)3.3; calcium channel, voltage-dependent, alpha 1I subunit; calcium channel, voltage-dependent, T type, alpha 1I subunit; CaVT.3; hypothetical gene supported by NM_020084; low voltage-activated T-type calcium channel alpha-1 subunit (CACNA1I); low-voltage-activated calcium channel alpha13.3; RP1-172B20.4; voltage-dependent calcium channel; Voltage-dependent T-type calcium channel subunit alpha-1I; Voltage-gated calcium channel subunit alpha Cav3.3
基因别名: Ca(V)3.3; CACNA1I; Cav3.3; KIAA1120
UniProt ID: (Human) Q9NZC8, (Rat) Q9Z0Y8
Entrez Gene ID: (Human) 8911, (Rat) 56827, (Mouse) 239556
transport
signal transduction
neuronal action potential
sperm motility
sleep
regulation of ion transmembrane transport
positive regulation of calcium ion-dependent exocytosis
calcium ion import
calcium ion transmembrane transport
membrane depolarization during action potential
calcium ion transport into cytosol
calcium ion transport
ion transmembrane transport
regulation of membrane potential
