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CACNA2D1 Antibody (PA5-109474) in WB
Western blot analysis of CACNA2D1 in extracts of various cell lines. Samples were incubated with CACNA2D1 Polyclonal antibody (Product # PA5-109474) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
产品信息
PA5-109474
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 550-800 of human CACNA2D1 (NP_000713.2).
偶联物
形式
Liquid
浓度
1.99 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2854885
产品详细信息
Immunogen sequence: DIKVEIRNKM IDGESGEKTF RTLVKSQDER YIDKGNRTYT WTPVNGTDYS LALVLPTYSF YYIKAKLEET ITQARSKKGK MKDSETLKPD NFEESGYTFI APRDYCNDLK ISDNNTEFLL NFNEFIDRKT PNNPSCNADL INRVLLDAGF TNELVQNYWS KQKNIKGVKA RFVVTDGGIT RVYPKEAGEN WQENPETYED SFYKRSLDND NYVFTAPYFN KSGPGAYESG IMVSKAVEIY IQGKLLKPAV V
靶标信息
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: calcium channel, L type, alpha 2 polypeptide; calcium channel, voltage-dependent, alpha 2/delta subunit 1; DHP; dihydropyridine-sensitive calcium channel alpha 2; dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit; H_DJ0560O14.1; Voltage-dependent calcium channel subunit alpha-2/delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1; WUGSC:H_DJ0560O14.1
基因别名: Ca(v)alpha2delta1; CACNA2; CACNA2D1; CACNL2A; CCHL2A; LINC01112; lncRNA-N3; MHS3
UniProt ID: (Human) P54289, (Mouse) O08532
Entrez Gene ID: (Human) 781, (Mouse) 12293
calcium ion transport
regulation of calcium ion transport
regulation of ventricular cardiac muscle cell membrane repolarization
calcium ion transport into cytosol
cardiac conduction
calcium ion transmembrane transport via high voltage-gated calcium channel
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
regulation of membrane repolarization during action potential
positive regulation of high voltage-gated calcium channel activity
transport
ion transport
regulation of ion transmembrane transport
calcium ion transmembrane transport
