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产品信息
OSC00096W-100UL
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from the c-terminal region of human CACNB4 conjugated to blue carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen is homologous in many species including mouse and rat.
Specificity of this antibody: CACNB4.
靶标信息
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy and juvenile myoclonic epilepsy. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CAB4; calcium channel beta 4 subunit; Calcium channel voltage-dependent subunit beta 4; calcium channel, voltage-dependent, beta 4 subunit; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit; OTTHUMP00000207247; OTTHUMP00000207249; Voltage-dependent L-type calcium channel subunit beta-4
基因别名: 3110038O15Rik; CAB4; CACNB4; CACNLB4; Cchb4; EA5; EIG9; EJM; EJM4; EJM6; lh
UniProt ID: (Human) O00305, (Rat) D4A055, (Mouse) Q8R0S4
Entrez Gene ID: (Human) 785, (Rat) 58942, (Mouse) 12298
transport
cellular calcium ion homeostasis
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
neuromuscular junction development
adult walking behavior
gamma-aminobutyric acid secretion
neuronal action potential propagation
synaptic transmission, glutamatergic
cAMP metabolic process
spleen development
thymus development
Peyer's patch development
muscle fiber development
T cell receptor signaling pathway
detection of light stimulus involved in visual perception
membrane depolarization
cardiac conduction
calcium ion transmembrane transport
regulation of voltage-gated calcium channel activity
calcium ion transport
T cell differentiation
regulation of ion transmembrane transport
regulation of membrane potential
neurological system process
synaptic transmission, GABAergic
ion transport
