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产品信息
PA5-23500
产品规格
种属反应
Bovine,
Dog,
Human,
Non-human primate,
Pig
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acid 460-510 of human Cactin
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2541000
靶标信息
Cactin is a novel negative regulator of TLR signaling and reveals its capacity to target MHC Class III genes at the molecular and functional level. It is localized to the nucleus, which is critical for manifesting its inhibitory effects on TLR signaling. Experimental evidences show overexpression of Cactin suppresses TLR-induced activation of NF-kB and interferon-regulatory factor transcription factors and induction of TLR-responsive genes. It is also reported Cactin interacts with IkB-like protein and targets other proteins that are encoded by genes in the MHC Class III region of chromosome 6.
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生物信息学
蛋白别名: functional spliceosome-associated protein c; NY REN 24 antigen; NY-REN-24 antigen; Renal carcinoma antigen NY-REN-24; Splicing factor Cactin
基因别名: C19orf29; C20H19orf29; CACTIN; fSAPc; NY-REN-24
UniProt ID: (Human) Q8WUQ7
Entrez Gene ID: (Pig) 100521180, (Human) 58509, (Dog) 485055
mRNA splicing, via spliceosome
negative regulation of protein phosphorylation
multicellular organism development
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
negative regulation of interferon-beta production
negative regulation of interleukin-8 production
negative regulation of tumor necrosis factor production
negative regulation of toll-like receptor signaling pathway
innate immune response
negative regulation of type I interferon-mediated signaling pathway
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to tumor necrosis factor
