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Invitrogen
CALCRL Recombinant Rabbit Monoclonal Antibody (8H9L8)
FIGURE: 1 / 5
CALCRL Antibody (703811) in IHC
Sections of Rat dorsal root ganglia were dewaxed, microwaved in citric acid and incubated with Anti-CALCRL Recombinant Rabbit Monoclonal Antibody (Product # 703811, 1:500 dilution). Sections were then sequentially treated with biotinylated anti-rabbit IgG and AB solution. Sections were then developed in AEC and lightly counterstained with hematoxylin. Note, strong staining of small to medium diameter neurons. Inset, peptide neutralization control.
Product Details
703811
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
8H9L8
Immunogen
Peptides corresponding to human CALCRL [1) aa23-aa40 2) aa48-aa64]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2848243
Product Specific Information
This antibody is predicted to react with Mouse, Bovine.
Target Information
CRLR is a receptor for calcitonin gene-related peptide type 1. The activity of CRLR is mediated by G proteins which activate adenylyl cyclase. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B-cell/lung/testis, bome marrow, embryo, lung and synovium libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Calcitonin gene-related peptide type 1 receptor; Calcitonin receptor-like receptor; CGRP receptor; CGRP type 1 receptor; Cgrp1 receptor
Gene Aliases: CALCRL; CGRPR; CLR; CRLR; RATCRLR; RNCLR
UniProt ID: (Human) Q16602, (Rat) Q63118
Entrez Gene ID: (Human) 10203, (Rat) 25029
angiogenesis
cAMP biosynthetic process
calcium ion transport
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating G-protein coupled receptor signaling pathway
heart development
protein transport
positive regulation of cAMP biosynthetic process
receptor internalization
negative regulation of smooth muscle contraction
positive regulation of smooth muscle cell proliferation
negative regulation of inflammatory response
cellular response to sucrose stimulus
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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