Invitrogen

CALHM1 Polyclonal Antibody

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CALHM1 Antibody (PA5-113789) in WB

Western Blot of Mouse Intestine using a CALHM1 Polyclonal Antibody (Product # PA5-113789).

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产品信息

PA5-113789

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1.0 µg/mL

产品规格

种属反应

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Immunogen sequence: GITDQGTMNR LLTSWHKCKP PLRLGQEAPL MSNGWAGGEP RPPRKEVATY (aa 295-344).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2884304

产品详细信息

Immunogen sequence: GITDQGTMNR LLTSWHKCKP PLRLGQEAPL MSNGWAGGEP RPPRKEVATY

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Predicted homology: Cow: 93%; Dog: 93%; Horse: 85%; Human: 100%; Mouse: 93%; Pig: 86%; Rabbit: 93%; Rat: 100%

靶标信息

Alzheimers disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.

仅用于科研。不用于诊断过程。未经明确授权不得转售。