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CAS Antibody (PA5-21468) in ICC/IF
CAS Polyclonal Antibody detects CSE1L protein at nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: CSE1L stained by CAS Polyclonal Antibody (Product # PA5-21468) diluted at 1:1500. Red: phalloidin, a cytoskeleton marker, diluted at 1:200. Scale bar= 10 µm.
产品信息
PA5-21468
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 222 and 469 of CSE1L (Uniprot ID#P55060)
偶联物
形式
Liquid
浓度
0.59 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_11151862
产品详细信息
Recommended positive controls: 293T, A431, HeLa, HepG2, NIH-3T3, JC, BCL-1, C2C12, PC-12, Rat2.
Predicted reactivity: Mouse (99%), Rat (100%), Zebrafish (95%), Xenopus laevis (97%), Pig (100%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; CSE1 chromosome segregation 1 like; CSE1 chromosome segregation 1-like; Exp2; Exportin-2; Importin-alpha re-exporter; MGC117283; MGC130036; MGC130037
基因别名: 2610100P18Rik; AA407533; Capts; CAS; CSE1; CSE1L; XPO2
UniProt ID: (Human) P55060, (Mouse) Q9ERK4
Entrez Gene ID: (Human) 1434, (Mouse) 110750, (Rat) 362273
