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CASK Antibody (PA5-85785) in ICC/IF
CASK Polyclonal Antibody detects CASK protein by immunofluorescent analysis. Sample: DIV14 rat E18 primary cortical neurons were fixed in 4% paraformaldehyde at RT for 15 min. Green: CASK protein stained by CASK Polyclonal Antibody (Product # PA5-85785) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, stained by beta Tubulin 3/ Tuj1 antibody [GT1338] diluted at 1:500. Blue: Fluoroshield with DAPI .
产品信息
PA5-85785
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of mouse CASK.
偶联物
形式
Liquid
浓度
0.77 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2792921
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (92%), Rhesus Monkey (93%), Bovine (93%).
Positive Control: mouse brain, rat brain.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
CASK is a calcium/calmodulin-dependent serine protein kinase which is a MAGUK (membrane-associated guanylate kinase) protein family member. CASK is a scaffold protein and the encoded protein is located at synapses in the brain. CASK associates with FG syndrome 4, mental retardation, microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. CASK functions as a cytoskeletal membrane scaffold that coordinates signal transduction pathways within the cortical cytoskeleton.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calcium/calmodulin-dependent serine protein kinase; MGC7449; OTTHUMP00000023157; OTTHUMP00000023161; OTTHUMP00000023162; Peripheral plasma membrane protein CASK; RP23-278L4.1
基因别名: Cask; DXPri1; DXRib1; LIN-2; mLin-2; Pals3
UniProt ID: (Rat) Q62915, (Mouse) O70589
Entrez Gene ID: (Rat) 29647, (Mouse) 12361
transcription coactivator activity
calmodulin-dependent protein kinase activity
G-protein coupled receptor activity
protein binding
calmodulin binding
ATP binding
protein C-terminus binding
PDZ domain binding
protein complex binding
neurexin family protein binding
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
scaffold/adaptor protein
negative regulation of cell-matrix adhesion
protein complex assembly
protein phosphorylation
intracellular protein transport
G-protein coupled receptor signaling pathway
negative regulation of keratinocyte proliferation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of wound healing
calcium ion import
positive regulation of calcium ion import
negative regulation of cellular response to growth factor stimulus
regulation of nucleic acid-templated transcription
phosphorylation
