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产品信息
PA5-50372
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Fusion protein corresponding to residues near the C terminal of human cation channel, sperm associated 1
偶联物
形式
Liquid
浓度
1.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2635825
产品详细信息
The antibody detects endogenous levels of total CATSPER1 protein.
靶标信息
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cation channel sperm-associated protein 1; cation channel, sperm associated 1; CatSper1; hCatSper; sperm ion channel; sperm-associated cation channel 1
基因别名: CATSPER; CATSPER1; SPGF7
UniProt ID: (Human) Q8NEC5
Entrez Gene ID: (Human) 117144
multicellular organism development
spermatogenesis
fusion of sperm to egg plasma membrane
cell differentiation
sperm motility
response to progesterone
regulation of ion transmembrane transport
sperm-egg recognition
regulation of calcium ion transport
regulation of cilium beat frequency involved in ciliary motility
calcium ion transmembrane transport
membrane depolarization during action potential
