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CBF beta Antibody (PA5-119052) in IHC (P)
Immunohistochemistry analysis of CBF beta in paraffin-embedded Mouse Stomach tissue. Samples were incubated with polyclonal antibody (Product # PA5-119052) at a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.
产品信息
PA5-119052
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein Core Binding Factor Beta Subunit. The antigen corresponds to amino acid range 1-187 of the target protein.
偶联物
形式
Liquid
浓度
0.9 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2903552
靶标信息
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CBF-beta; Core-binding factor subunit beta; PEA2-beta; PEBP2-beta; Polyomavirus enhancer-binding protein 2 beta subunit; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit
基因别名: AI893578; Cbfb; PEA2; Pebp2; PEBP2b; Pebpb2
UniProt ID: (Mouse) Q08024
Entrez Gene ID: (Mouse) 12400
