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CBP Antibody (PA5-81159) in ICC/IF
Immunofluorescence staining of CBP in HeLa cells. Cells were fixed with 4% PFA, blocked with 10% serum, and then incubated with CBP Polyclonal Antibody (Product # PA5-81159, 1:1,000)(Figure A) or CBP Polyclonal Antibody and antigen (Figure B) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm and nucleus.
产品信息
PA5-81159
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to the C-terminus of the Human CREBBP
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2788395
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human CBP/CREBBP.
靶标信息
CBP for CREB-binding protein is a 265 kDa nuclear protein which probably has many of the properties expected of a CREB co-activator. It shows substantial sequence homology with p300.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CREB-binding protein; Histone lysine acetyltransferase CREBBP; Protein lactyltransferas CREBBP; Protein-lysine acetyltransferase CREBBP
基因别名: CBP; CREBBP; KAT3A; RSTS
UniProt ID: (Human) Q92793
Entrez Gene ID: (Human) 1387
core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
RNA polymerase II activating transcription factor binding
RNA polymerase II transcription coactivator activity
transcriptional repressor activity, RNA polymerase II transcription factor binding
p53 binding
chromatin binding
damaged DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
histone acetyltransferase activity
signal transducer activity
protein binding
transcription factor binding
zinc ion binding
acetyltransferase activity
peptide N-acetyltransferase activity
peroxisome proliferator activated receptor binding
MRF binding
SMAD binding
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
stimulatory C-type lectin receptor signaling pathway
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
protein complex assembly
protein acetylation
signal transduction
Notch signaling pathway
cell proliferation
regulation of smoothened signaling pathway
viral process
histone acetylation
N-terminal peptidyl-lysine acetylation
positive regulation of type I interferon production
cellular response to UV
homeostatic process
embryonic digit morphogenesis
regulation of apoptotic process
cellular lipid metabolic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
positive regulation of cell adhesion molecule production
regulation of transcription from RNA polymerase II promoter in response to hypoxia
response to interleukin-1
cell-cell adhesion
regulation of cellular response to heat
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of NIK/NF-kappaB signaling
beta-catenin-TCF complex assembly
